You’re more like your father than your mother
The most important scientific breakthroughs of 2014
The findings could give scientists more insight into how diseases and conditions are caused by gene expression of thousands of DNA, of which several hundred imprinted genes – rather than out of the 95 initially thought – could be in favour of the father.
Professor and author of the study paper Fernando Pardo-Manuel de Villena said: “This is an exceptional new research finding that opens the door to an entirely new area of exploration in human genetics.”
The study on the offspring of three genetically-diverse strains of “Collaborative Cross” mice is hoped to shed light on how mutations show up in complex diseases such as diabetes, heart disease, schizophrenia and obesity, according to Science Daily.
James Crowley, assistant professor of genetics, selected strains of mice that descended from a subspecies that evolved on different continents and each type was used as both father and mother.
When the nine baby mice reached adulthood, the researchers measured gene expression in four different kinds of tissue, including RNA sequencing in the brain.
“This expression level is dependent on the mother or the father,” Pardo-Manuel de Villena said.
“We now know that mammals express more genetic variance from the father. So imagine that a certain kind of mutation is bad. If inherited from the mother, the gene wouldn’t be expressed as much as it would be if it were inherited from the father.
“So, the same bad mutation would have different consequences in disease if it were inherited from the mother or from the father.”
The study is published in the journal Nature Genetics.
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